an·ti·sense DNA. the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene. Farlex Partner Medical Dictionary Question: A sense strand of DNA that encodes for a small peptide is: 5’-ATGTCGAGTGAT-3’ what is the antisense DNA strand complimentary to this strand? 5’-_____-3’ What is the mRNA sequence that would be translated from the sense strand of DNA described above? 5’-_____-3’ What is the amino acid sequence (3 letter codes OK) of “Antisense Oligonucleotides” (ASOs) are short-length single sequences of deoxynucleotides, 12–28 bases, that are synthesized to be complementary to a sequence of mRNA or pre-mRNA to generate a DNA/RNA heteroduplex; in this way, they can regulate the target expression. Antisense LNA GapmeRs are single-stranded antisense oligonucleotides (ASOs) that catalyze nuclear RNase H-dependent degradation of complementary RNA targets (Fig. 1). They are 16 nucleotides long and are enriched with LNA (Locked Nucleic Acids) nucleotides in the flanking regions and DNA nucleotides in an LNA-free central gap. DNA strand is the template strand that has nucleotide sequence on it which is read by RNA polymerases. The Rna polymerase reads the template strand and with the help of base pairing rule codes for m-RNA. The use of antisense oligonucleotides (ASOs) is a promising approach to gene silencing. ASOs are small single-stranded pieces of DNA that bind via complementary base-pair binding to the intracellular mRNA transcript (Figure). In HD, ASOs prevent the transcription of mHtt. ASOs have been found to reduce a number of different mHtt-associated .

what is antisense dna